03-P045 Wnt11/Pk1a-mediated planar cell polarity signalling orchestrates epithelial organ morphogenesis by regulating N-cadherin dependent cell adhesion forces
نویسندگان
چکیده
Wnt11/Pk1a-mediated planar cell polarity signalling orchestrates epithelial organ morphogenesis by regulating N-cadherin dependent cell adhesion forces Pablo Oteiza, Mathias Koeppen, Michael Krieg, Stephan Preibisch, Steffen Haertel, Daniel Mueller, Carl-Philipp Heisenberg, Miguel Concha 1 University of Chile, Santiago, Chile 2 Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany 3 BioZ, Dresden, Germany 4 SCIAN, Santiago, Chile 5 Gulbenkian Institute, Lisbon, Portugal
منابع مشابه
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Wnt11/Pk1a-mediated planar cell polarity signalling orchestrates epithelial organ morphogenesis by regulating N-cadherin dependent cell adhesion forces Pablo Oteiza, Mathias Koeppen, Michael Krieg, Stephan Preibisch, Steffen Haertel, Daniel Mueller, Carl-Philipp Heisenberg, Miguel Concha 1 University of Chile, Santiago, Chile 2 Max Planck Institute for Molecular Cell Biology and Genetics, Dresd...
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Wnt11/Pk1a-mediated planar cell polarity signalling orchestrates epithelial organ morphogenesis by regulating N-cadherin dependent cell adhesion forces Pablo Oteiza, Mathias Koeppen, Michael Krieg, Stephan Preibisch, Steffen Haertel, Daniel Mueller, Carl-Philipp Heisenberg, Miguel Concha 1 University of Chile, Santiago, Chile 2 Max Planck Institute for Molecular Cell Biology and Genetics, Dresd...
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Organ formation requires the precise assembly of progenitor cells into a functional multicellular structure. Mechanical forces probably participate in this process but how they influence organ morphogenesis is still unclear. Here, we show that Wnt11- and Prickle1a-mediated planar cell polarity (PCP) signalling coordinates the formation of the zebrafish ciliated laterality organ (Kupffer's vesic...
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Polarised tissue elongation during morphogenesis involves cells within epithelial sheets or tubes making and breaking intercellular contacts in an oriented manner. Growing evidence suggests that cell adhesion can be modulated by endocytic trafficking of E-cadherin (E-cad), but how this process can be polarised within individual cells is poorly understood. The Frizzled (Fz)-dependent core planar...
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Scribble (Scrib) is a conserved polarity protein required in Drosophila melanogaster for synaptic function, neuroblast differentiation, and epithelial polarization. It is also a tumor suppressor. In rodents, Scrib has been implicated in receptor recycling and planar polarity but not in apical/basal polarity. We now show that knockdown of Scrib disrupts adhesion between Madin-Darby canine kidney...
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عنوان ژورنال:
- Mechanisms of Development
دوره 126 شماره
صفحات -
تاریخ انتشار 2009